Gkenn D. Steele, Theodore L. Phillips. Bruce A. Chabner
Penerbit
:
BC Decker, -, 2000
Kolasi
:
-
Digital Copy
:
5
Pinjaman Aktif
:
0
Synopsis
:
The extraordinary advances in molecular genetics during the past decade
have
established
beyond doubt that there is a Mendelian
inherited
basis for a subset of
virtually all
forms of
cancer.
Specifically, more than 30 hereditary cancer
syndromes have been shown to harbor germ-line
mutations. These culprit molecular genetic factors include
oncogenes such as the
RET
protooncogene for the multiple endocrine
neoplasia
type 2 syndromes, the mismatch repair
genes
(hMSH2,
hMLH1) in hereditary nonpolyposis
colorectal cancer (HNPCC) of the Lynch I and
Lynch II syndrome variants, and tumor suppressor genes. Examples of the latter include
APC,
which predisposes to
familial
adenomatous
polyposis
(FAP), and
BRCA1
and BRCA2 mutations in
hereditary breast
cancer, the subject
of
this
chapter.
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